Altered CD8+ T-Cell Lymphocyte Function and TC1 Cell Stemness Contribute to Enhanced Malignant Tumor Properties in Murine Models of Sleep Apnea | Zendy

Mahzad Akbarpour | Zendy; Abdelnaby Khalyfa | Zendy; Zhuanghong Qiao | Zendy; Alex GilelesHillel | Zendy; Isaac Almendros | Zendy; Ramón Farré | Zendy; David Gozal | Zendy

Open Access

Altered CD8+ T-Cell Lymphocyte Function and TC1 Cell Stemness Contribute to Enhanced Malignant Tumor Properties in Murine Models of Sleep Apnea

Author(s) -

Mahzad Akbarpour,

Abdelnaby Khalyfa,

Zhuanghong Qiao,

Alex GilelesHillel,

Isaac Almendros,

Ramón Farré,

David Gozal

Publication year - 2016

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/zsw040

Subject(s) - cytotoxic t cell , cd8 , tumor microenvironment , granzyme b , immunology , population , cancer research , immune system , medicine , biology , in vitro , biochemistry , environmental health

The presence of obstructive sleep apnea (OSA) in patients with cancer appears to be accompanied by poorer outcomes. However, the mechanisms underlying such association are unknown. Tumor infiltrating lymphocytes (TILs), including CD8+ T cells, function as cytotoxic T lymphocytes (CTLs) and mount immune responses to cancer by the release of cytolytic enzymes, including granzyme B (GzmB), perforin (Prf), and cytokines such as interferon (IFN)-γ.

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