Objective, but Not Subjective, Sleepiness is Associated With Inflammation in Sleep Apnea | Zendy

Yun Li | Zendy; Alexandros N. Vgontzas | Zendy; Julio FernándezMendoza | Zendy; Ilia Kritikou | Zendy; Maria Basta | Zendy; Slobodanka Pejovic | Zendy; Jordan Gaines | Zendy; Edward O. Bixler | Zendy

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Objective, but Not Subjective, Sleepiness is Associated With Inflammation in Sleep Apnea

Author(s) -

Yun Li,

Alexandros N. Vgontzas,

Julio FernándezMendoza,

Ilia Kritikou,

Maria Basta,

Slobodanka Pejovic,

Jordan Gaines,

Edward O. Bixler

Publication year - 2016

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/zsw033

Subject(s) - sleep apnea , obstructive sleep apnea , medicine , apnea , sleep (system call) , inflammation , polysomnography , psychology , anesthesia , computer science , operating system

Objective and subjective measures of excessive daytime sleepiness (EDS) are only weakly associated. No study, however, has examined whether these two measures of EDS differ in terms of underlying mechanisms and prognostic value. Pro-inflammatory cytokines, that is, interleukin-6 (IL-6) appear to promote sleepiness/fatigue, while the stress hormone cortisol promotes vigilance. We hypothesized that objective sleepiness is associated with increased levels of IL-6 and decreased levels of cortisol.

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