HLA-DR2 and Narcolepsy | Zendy

Michel Billiard | Zendy; J Seignalet | Zendy; A Besset | Zendy; J Cadilhac | Zendy

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HLA-DR2 and Narcolepsy

Author(s) -

Michel Billiard,

J Seignalet,

A Besset,

J Cadilhac

Publication year - 1986

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/9.1.149

Subject(s) - narcolepsy , penetrance , human leukocyte antigen , cataplexy , inheritance (genetic algorithm) , immunology , medicine , genetics , biology , psychiatry , phenotype , antigen , modafinil , gene

A positive association between HLA-DR2, DQw1, and narcolepsy was documented in 23 French caucasoid narcoleptic patients, 18 who were heterozygous for DR2 and 5 who were possibly homozygous. An autoimmune mechanism of narcolepsy is proposed with three successive stages, as well as relevant methodology for further investigation. A dominant mode of inheritance of narcolepsy, with an incomplete penetrance, is suggested although not yet evidenced.

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