Muscarinic Cholinergic Receptors and the Canine Model of Narcolepsy | Zendy

Thomas S. Kilduff | Zendy; S. Scott Bowersox | Zendy; Kenneth I. Kaitin | Zendy; Theodore L. Baker | Zendy; Roland D. Ciaranello | Zendy; William C. Dement | Zendy

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Muscarinic Cholinergic Receptors and the Canine Model of Narcolepsy

Author(s) -

Thomas S. Kilduff,

S. Scott Bowersox,

Kenneth I. Kaitin,

Theodore L. Baker,

Roland D. Ciaranello,

William C. Dement

Publication year - 1986

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/9.1.102

Subject(s) - muscarinic acetylcholine receptor , narcolepsy , cholinergic , neuroscience , receptor , medicine , cataplexy , muscarinic acetylcholine receptor m2 , muscarinic acetylcholine receptor m1 , pharmacology , muscarinic acetylcholine receptor m4 , psychology , neurology

The role of the muscarinic cholinergic receptor in narcolepsy was examined using radioligand binding to various brain regions of normal and genetically narcoleptic Doberman pinschers. In this multi-litter study, a previous report of a proliferation of muscarinic cholinergic receptors in the brainstem was confirmed, and the concentration of the M2 receptor subtype, in particular, was elevated. This up-regulation of brainstem cholinergic receptors suggests a problem with release of acetylcholine, which, together with previous reports of an impairment of dopamine release, may be indicative of a fundamental membrane problem in narcolepsy.

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