REM Sleep Deprivation Effect on Apomorphine-Induced Gnawing Is Reversed by Dexamethasone | Zendy

L. CastilloMart nez | Zendy; Jun Kubota | Zendy; Marilyn Warren | Zendy; Ronaldo Henderson | Zendy; Manuelita Phillips | Zendy; Henry L. Schreiber | Zendy

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REM Sleep Deprivation Effect on Apomorphine-Induced Gnawing Is Reversed by Dexamethasone

Author(s) -

L. CastilloMart nez,

Jun Kubota,

Marilyn Warren,

Ronaldo Henderson,

Manuelita Phillips,

Henry L. Schreiber

Publication year - 1985

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/8.3.283

Subject(s) - apomorphine , privation , endocrinology , dexamethasone , medicine , sleep deprivation , maternal deprivation , glucocorticoid , catecholamine , rapid eye movement sleep , psychology , anesthesia , dopaminergic , circadian rhythm , dopamine , electroencephalography , psychiatry

Glucocorticoid feedback was manipulated in rats deprived of REM for six days or left undisturbed in their home cages. One half of each group received concurrent dexamethasone (400 micrograms/kg), while the other half received corn oil. On test day, rats were observed for 5 min, injected with apomorphine (0.8 mg/kg, i.p.), and again observed. Dexamethasone revealed REM-deprivation-enhanced stereotypical gnawing, but had no effect on REM-deprivation-reduced rearing, suggesting the involvement of catecholamine depletion by non-specific stress-related factors in the former REM deprivation effect.

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