Effects of Flurazepam on Sleep and Growth Hormone Release During Sleep In Healthy Subjects | Zendy

Elliot D. Weitzman | Zendy; Charles P. Pollak | Zendy

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Effects of Flurazepam on Sleep and Growth Hormone Release During Sleep In Healthy Subjects

Author(s) -

Elliot D. Weitzman,

Charles P. Pollak

Publication year - 1982

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/5.4.343

Subject(s) - polysomnography , sleep (system call) , flurazepam , medicine , placebo , slow wave sleep , growth hormone , sleep onset , sleep stages , hormone , endocrinology , anesthesia , insomnia , electroencephalography , pharmacology , apnea , psychiatry , benzodiazepine , receptor , alternative medicine , pathology , computer science , operating system

We studied the effect of flurazepam, a known suppressor of stages 3 and 4 of sleep, on nocturnal sleep patterns and on growth hormone release immediately following sleep onset in normal young adults. Polysomnography and sampling of growth hormone (every 20 min for 26 h) were performed before and after 2 weeks of nightly flurazepam (30 mg, 8 subjects) or placebo (8 subjects) administration. There were no significant changes in growth hormone release in spite of a significant decrease in stage 4 sleep (69%) and total waking time (46%) and an increase in total sleep time (23%) in the drug group. REM sleep was not changed. These results indicate that the normal GH release following sleep onset continues to occur despite stage 4 suppression by pharmacological means.

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