Abnormally Low Serum Acylcarnitine Levels in Narcolepsy Patients | Zendy

Taku Miyagawa | Zendy; Hiroko Miyadera | Zendy; Susumu Tanaka | Zendy; Minae Kawashima | Zendy; Mihoko Shimada | Zendy; Yutaka Honda | Zendy; Katsushi Tokunaga | Zendy; Makoto Honda | Zendy

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Abnormally Low Serum Acylcarnitine Levels in Narcolepsy Patients

Author(s) -

Taku Miyagawa,

Hiroko Miyadera,

Susumu Tanaka,

Minae Kawashima,

Mihoko Shimada,

Yutaka Honda,

Katsushi Tokunaga,

Makoto Honda

Publication year - 2011

Publication title -

sleep

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/34.3.349

Subject(s) - narcolepsy , endocrinology , medicine , cataplexy , carnitine , taurine , biology , neurology , biochemistry , psychiatry , amino acid

Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, and REM sleep abnormalities. A genome-wide association study identified a novel narcolepsy-related single nucleotide polymorphism (SNP), rs5770917, which is located adjacent to CPT1B (carnitine palmitoyltransferase 1B). In this study, we analyzed the CPT1B expression level and measured the carnitine fractions in blood samples obtained from narcolepsy patients and control subjects to test the hypothesis that fatty acid β-oxidation is altered in narcolepsy.

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