The Dopamine Transporter is Decreased in the Striatum of Subjects with Restless Legs Syndrome | Zendy

Christopher J. Earley | Zendy; Hiroto Kuwabara | Zendy; Dean F. Wong | Zendy; Charlene E. Gamaldo | Zendy; Rachel Marie E. Salas | Zendy; James Robert Bras̆ić | Zendy; Hayden T. Ravert | Zendy; Robert F. Dannals | Zendy; Richard P. Allen | Zendy

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The Dopamine Transporter is Decreased in the Striatum of Subjects with Restless Legs Syndrome

Author(s) -

Christopher J. Earley,

Hiroto Kuwabara,

Dean F. Wong,

Charlene E. Gamaldo,

Rachel Marie E. Salas,

James Robert Bras̆ić,

Hayden T. Ravert,

Robert F. Dannals,

Richard P. Allen

Publication year - 2011

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/34.3.341

Subject(s) - dopamine transporter , restless legs syndrome , putamen , striatum , dopamine , medicine , psychology , endocrinology , dopaminergic , neuroscience , neurology

Prior studies, all using SPECT techniques, failed to find any differences for dopamine transporter (DAT) in restless legs syndrome (RLS) subjects. The distinct pharmacokinetic properties associated with SPECT-determined DAT along with rapid biodynamic changes in DAT may, however, have missed membrane-bound DAT differences. The current studies assessed real-time DAT binding potentials (BP) in striatum of RLS patients using (11)C-methylphenidate and PET techniques.

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