Sleep Related Changes in Blood Pressure in Hypocretin-Deficient Narcoleptic Mice | Zendy

Stefano Bastianini | Zendy; Alessandro Silvani | Zendy; Chiara Berteotti | Zendy; JeanLuc Elghozi | Zendy; Carlo Franzini | Zendy; Pierluigi Lenzi | Zendy; Viviana Lo Martire | Zendy; Giovanna Zoccoli | Zendy

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Sleep Related Changes in Blood Pressure in Hypocretin-Deficient Narcoleptic Mice

Author(s) -

Stefano Bastianini,

Alessandro Silvani,

Chiara Berteotti,

JeanLuc Elghozi,

Carlo Franzini,

Pierluigi Lenzi,

Viviana Lo Martire,

Giovanna Zoccoli

Publication year - 2011

Publication title -

sleep

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/34.2.213

Subject(s) - wakefulness , narcolepsy , orexin , blood pressure , endocrinology , sleep (system call) , non rapid eye movement sleep , medicine , cataplexy , rapid eye movement sleep , neuroscience , psychology , neurology , electroencephalography , receptor , neuropeptide , computer science , operating system

Although blood pressure during sleep and the difference in blood pressure between sleep and wakefulness carry prognostic information, little is known on their central neural mechanisms. Hypothalamic neurons releasing hypocretin (orexin) peptides control wake-sleep behavior and autonomic functions and are lost in narcolepsy-cataplexy. We investigated whether chronic lack of hypocretin signaling alters blood pressure during sleep.

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