Peripheral Blood Leukocyte Gene Expression Patterns and Metabolic Parameters in Habitually Snoring and Non-Snoring Children with Normal Polysomnographic Findings
Author(s) -
Abdelnaby Khalyfa,
Sina A. Gharib,
Jinkwan Kim,
Óscar Sans Capdevila,
David Gozal,
Rakesh Bhattacharjee,
Mohamed Hegazi
Publication year - 2011
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.1093/sleep/34.2.153
Subject(s) - cohort , glucose homeostasis , transcriptome , medicine , polysomnography , biology , gene , insulin resistance , gene expression , endocrinology , bioinformatics , insulin , genetics , apnea
Children who snore but do not have gas exchange abnormalities or alterations of sleep architecture have primary snoring (PS). Since increasing evidence suggest that PS may be associated with morbidity, we hypothesized that assessing genome-wide gene expression in peripheral blood leukocytes (PBL) will identify a distinct signature in PS children.
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