Prospective Trial of Efficacy and Safety of Ondansetron and Fluoxetine in Patients with Obstructive Sleep Apnea Syndrome | Zendy

Bharati Prasad | Zendy; Miodrag Radulovački | Zendy; Christopher O. Olopade | Zendy; James J. Herdegen | Zendy; Thomas C. Logan | Zendy; David W. Carley | Zendy

Open Access

Prospective Trial of Efficacy and Safety of Ondansetron and Fluoxetine in Patients with Obstructive Sleep Apnea Syndrome

Author(s) -

Bharati Prasad,

Miodrag Radulovački,

Christopher O. Olopade,

James J. Herdegen,

Thomas C. Logan,

David W. Carley

Publication year - 2010

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/33.7.982

Subject(s) - obstructive sleep apnea , ondansetron , medicine , fluoxetine , sleep apnea , anesthesia , sleep (system call) , prospective cohort study , nausea , serotonin , receptor , computer science , operating system

Incremental withdrawal of serotonin during wake to sleep transition is postulated as a key mechanism that renders the pharyngeal airway collapsible. While serotonin promotion with reuptake inhibitors have demonstrated modest beneficial effects during NREM sleep on obstructive sleep apnea (OSA), animal studies suggest a potential therapeutic role for selective serotonin receptor antagonists (5-HT3) in REM sleep. We aimed to test the hypothesis that a combination of ondansetron (Ond) and fluoxetine (Fl) may effectively reduce expression of disordered breathing during REM and NREM sleep in patients with OSA.

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