Effects of Paraxanthine and Caffeine on Sleep, Locomotor Activity, and Body Temperature in Orexin/Ataxin-3 Transgenic Narcoleptic Mice | Zendy

Masashi Okuro | Zendy; Nobuhiro Fujiki | Zendy; Nozomu Kotorii | Zendy; Yuji Ishimaru | Zendy; Pierre Sokoloff | Zendy; Seiji Nishino | Zendy

Open Access

Effects of Paraxanthine and Caffeine on Sleep, Locomotor Activity, and Body Temperature in Orexin/Ataxin-3 Transgenic Narcoleptic Mice

Author(s) -

Masashi Okuro,

Nobuhiro Fujiki,

Nozomu Kotorii,

Yuji Ishimaru,

Pierre Sokoloff,

Seiji Nishino

Publication year - 2010

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/33.7.930

Subject(s) - orexin , caffeine , paraxanthine , narcolepsy , sleep (system call) , endocrinology , medicine , genetically modified mouse , chemistry , transgene , pharmacology , modafinil , biochemistry , gene , neuropeptide , metabolism , receptor , cytochrome p450 , cyp1a2 , computer science , operating system

Caffeine, an adenosine A1 and A2a receptor antagonist, is a widely consumed stimulant and also used for the treatment of hypersomnia; however, the wake-promoting potency of caffeine is often not strong enough, and high doses may induce side effects. Caffeine is metabolized to paraxanthine, theobromine, and theophylline. Paraxanthine is a central nervous stimulant and exhibits higher potency at A1 and A2 receptors, but has lower toxicity and lesser anxiogenic effects than caffeine.

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