Interleukin-1 Inhibits Putative Cholinergic Neurons in Vitro and REM Sleep when Microinjected into the Rat Laterodorsal Tegmental Nucleus | Zendy

Dario Brambilla | Zendy; Isabella Barajon | Zendy; Susanna Bianchi | Zendy; Mark R. Opp | Zendy; Luca Imeri | Zendy

Open Access

Interleukin-1 Inhibits Putative Cholinergic Neurons in Vitro and REM Sleep when Microinjected into the Rat Laterodorsal Tegmental Nucleus

Author(s) -

Dario Brambilla,

Isabella Barajon,

Susanna Bianchi,

Mark R. Opp,

Luca Imeri

Publication year - 2010

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/33.7.919

Subject(s) - cholinergic , cholinergic neuron , glutamatergic , neuroscience , brainstem , acetylcholine , rapid eye movement sleep , sleep (system call) , endocrinology , biology , medicine , glutamate receptor , electroencephalography , computer science , operating system , receptor

REM sleep is suppressed during infection, an effect mimicked by the administration of cytokines such as interleukin-1 (IL-1). In spite of this observation, brain sites and neurochemical systems mediating IL-1-induced suppression of REM sleep have not been identified. Cholinergic neurons in the brainstem laterodorsal tegmental nucleus (LDT) are part of the neuronal circuitry responsible for REM sleep generation. Since IL-1 inhibits acetylcholine synthesis and release, the aim of this study was to test the two different, but related hypotheses. We hypothesized that IL-1 inhibits LDT cholinergic neurons, and that, as a result of this inhibition, IL-1 suppresses REM sleep.

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