Anti-Tribbles Homolog 2 Autoantibodies in Japanese Patients with Narcolepsy | Zendy

Hiromi Toyoda | Zendy; Susumu Tanaka | Zendy; Taku Miyagawa | Zendy; Yutaka Honda | Zendy; Katsushi Tokunaga | Zendy; Makoto Honda | Zendy

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Anti-Tribbles Homolog 2 Autoantibodies in Japanese Patients with Narcolepsy

Author(s) -

Hiromi Toyoda,

Susumu Tanaka,

Taku Miyagawa,

Yutaka Honda,

Katsushi Tokunaga,

Makoto Honda

Publication year - 2010

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/33.7.875

Subject(s) - cataplexy , narcolepsy , autoantibody , human leukocyte antigen , autoimmunity , medicine , immunology , sleep disorder , antibody , antigen , psychiatry , insomnia , neurology

Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness and cataplexy. The association with human leukocyte antigen (HLA)-DQB1*0602 and T-cell receptor alpha locus suggests that autoimmunity plays a role in narcolepsy. A recent study reported an increased prevalence of autoantibodies against Tribbles homolog 2 (TRIB2) in patients with narcolepsy. To replicate this finding, we examined anti-TRIB2 autoantibodies in Japanese patients with narcolepsy.

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