Diffusion Tensor Imaging in Idiopathic REM Sleep Behavior Disorder Reveals Microstructural Changes in the Brainstem, Substantia Nigra, Olfactory Region, and Other Brain Regions | Zendy

Marcus M. Unger | Zendy; Marcus Belke | Zendy; Katja Menzler | Zendy; Johannes T. Heverhagen | Zendy; Boris Keil | Zendy; Karin StiasnyKolster | Zendy; Felix Rosenow | Zendy; Nico J. Diederich | Zendy; Geert Mayer | Zendy; Jens Carsten Möller | Zendy; Wolfgang H. Oertel | Zendy; Susanne Knake | Zendy

Open Access

Diffusion Tensor Imaging in Idiopathic REM Sleep Behavior Disorder Reveals Microstructural Changes in the Brainstem, Substantia Nigra, Olfactory Region, and Other Brain Regions

Author(s) -

Marcus M. Unger,

Marcus Belke,

Katja Menzler,

Johannes T. Heverhagen,

Boris Keil,

Karin StiasnyKolster,

Felix Rosenow,

Nico J. Diederich,

Geert Mayer,

Jens Carsten Möller,

Wolfgang H. Oertel,

Susanne Knake

Publication year - 2010

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/33.6.767

Subject(s) - substantia nigra , brainstem , diffusion mri , neuroscience , rem sleep behavior disorder , sleep (system call) , rapid eye movement sleep , psychology , medicine , polysomnography , electroencephalography , magnetic resonance imaging , dopamine , dopaminergic , radiology , computer science , operating system

Idiopathic rapid eye movement sleep behavior disorder (iRBD)--a parasomnia characterized by dream enactments--is a risk marker for the development of Parkinson disease (PD) and other alpha-synucleinopathies. The pathophysiology of iRBD is likely due to dysfunction of brainstem nuclei that regulate REM sleep. Diffusion tensor imaging (DTI) is a method for studying microstructural brain tissue integrity in vivo. We investigated whether DTI detects microstructural abnormalities in the brain of patients with iRBD--compared with age-matched control subjects--as an in vivo potential indicator for changes related to "preclinical (premotor)" neuropathology in PD.

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