Abnormal Sleep/Wake Dynamics in Orexin Knockout Mice | Zendy

Cecilia Diniz Behn | Zendy; Elizabeth B. Klerman | Zendy; Takatoshi Mochizuki | Zendy; ShihChieh Lin | Zendy; Thomas E. Scammell | Zendy

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Abnormal Sleep/Wake Dynamics in Orexin Knockout Mice

Author(s) -

Cecilia Diniz Behn,

Elizabeth B. Klerman,

Takatoshi Mochizuki,

ShihChieh Lin,

Thomas E. Scammell

Publication year - 2010

Publication title -

sleep

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/33.3.297

Subject(s) - narcolepsy , wakefulness , non rapid eye movement sleep , orexin , neuroscience , sleep (system call) , psychology , electroencephalography , medicine , neurology , neuropeptide , receptor , computer science , operating system

Narcolepsy with cataplexy is caused by a loss of orexin (hypocretin) signaling, but the physiologic mechanisms that result in poor maintenance of wakefulness and fragmented sleep remain unknown. Conventional scoring of sleep cannot reveal much about the process of transitioning between states or the variations within states. We developed an EEG spectral analysis technique to determine whether the state instability in a mouse model of narcolepsy reflects abnormal sleep or wake states, faster movements between states, or abnormal transitions between states.

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