Genetic Evidence for a Role for Protein Kinase A in the Maintenance of Sleep and Thalamocortical Oscillations | Zendy

Kevin M. Hellman | Zendy; Pepe J. Hernandez | Zendy; Alice Park | Zendy; Ted Abel | Zendy

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Genetic Evidence for a Role for Protein Kinase A in the Maintenance of Sleep and Thalamocortical Oscillations

Author(s) -

Kevin M. Hellman,

Pepe J. Hernandez,

Alice Park,

Ted Abel

Publication year - 2010

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/33.1.19

Subject(s) - neuroscience , hippocampus , protein kinase a , hippocampal formation , sleep (system call) , transgene , synaptic plasticity , biology , neuroscience of sleep , electroencephalography , psychology , wakefulness , kinase , microbiology and biotechnology , genetics , receptor , gene , computer science , operating system

Genetic manipulation of cAMP-dependent protein kinase A (PKA) in Drosophila has implicated an important role for PKA in sleeplwake state regulation. Here, we characterize the role of this signaling pathway in the regulation of sleep using electroencephalographic (EEG) and electromyographic (EMG) recordings in R(AB) transgenic mice that express a dominant negative form of the regulatory subunit of PKA in neurons within cortex and hippocampus. Previous studies have revealed that these mutant mice have reduced PKA activity that results in the impairment of hippocampus-dependent long-term memory and long-lasting forms of hippocampal synaptic plasticity.

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