Elevated Anti-Streptococcal Antibodies in Patients with Recent Narcolepsy Onset | Zendy

Adi Aran | Zendy; Ling Lin | Zendy; Soňa Nevšímalová | Zendy; Giuseppe Plazzi | Zendy; Seung Chul Hong | Zendy; Karin Weiner | Zendy; Jamie M. Zeitzer | Zendy; Emmanuel Mignot | Zendy

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Elevated Anti-Streptococcal Antibodies in Patients with Recent Narcolepsy Onset

Author(s) -

Adi Aran,

Ling Lin,

Soňa Nevšímalová,

Giuseppe Plazzi,

Seung Chul Hong,

Karin Weiner,

Jamie M. Zeitzer,

Emmanuel Mignot

Publication year - 2009

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/32.8.979

Subject(s) - narcolepsy , cataplexy , medicine , immunology , autoimmunity , streptococcus , gastroenterology , antibody , biology , neurology , psychiatry , bacteria , genetics

Narcolepsy-cataplexy has long been thought to have an autoimmune origin. Although susceptibility to narcolepsy, like many autoimmune conditions, is largely genetically determined, environmental factors are involved based on the high discordance rate (approximately 75%) of monozygotic twins. This study evaluated whether Streptococcus pyogenes and Helicobacter pylori infections are triggers for narcolepsy.

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