GABAergic Antagonism of the Central Nucleus of the Amygdala Attenuates Reductions in Rapid Eye Movement Sleep After Inescapable Footshock Stress | Zendy

Xianling Liu | Zendy; Linghui Yang | Zendy; Laurie L. Wellman | Zendy; Xiangdong Tang | Zendy; Larry D. Sanford | Zendy

Open Access

GABAergic Antagonism of the Central Nucleus of the Amygdala Attenuates Reductions in Rapid Eye Movement Sleep After Inescapable Footshock Stress

Author(s) -

Xianling Liu,

Linghui Yang,

Laurie L. Wellman,

Xiangdong Tang,

Larry D. Sanford

Publication year - 2009

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/32.7.888

Subject(s) - amygdala , rapid eye movement sleep , neuroscience , gabaergic , sleep (system call) , central nucleus of the amygdala , antagonism , eye movement , neuroscience of sleep , nucleus , psychology , medicine , non rapid eye movement sleep , inhibitory postsynaptic potential , receptor , computer science , operating system

Rapid eye movement sleep (REM) appears to be especially susceptible to the effects of stress; inescapable footshock stress (IS) can produce reductions in REM that can occur without recovery sleep. The amygdala has well-established roles in stress and emotion; the central nucleus of the amygdala (CNA) projects to REM regulatory regions in the brainstem and has been found to play a key role in the regulation of REM. The objective of this study was to determine whether the reduction in REM induced by IS could be regulated by CNA and brainstem regions.

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