Altered Iron Metabolism in Lymphocytes from Subjects with Restless Legs Syndrome | Zendy

Christopher J. Earley | Zendy; Padmavathi Ponnuru | Zendy; Xinsheng Wang | Zendy; Stephanie M. Patton | Zendy; James R. Connor | Zendy; John L. Beard | Zendy; Dennis D. Taub | Zendy; Richard P. Allen | Zendy

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Altered Iron Metabolism in Lymphocytes from Subjects with Restless Legs Syndrome

Author(s) -

Christopher J. Earley,

Padmavathi Ponnuru,

Xinsheng Wang,

Stephanie M. Patton,

James R. Connor,

John L. Beard,

Dennis D. Taub,

Richard P. Allen

Publication year - 2008

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/31.6.847

Subject(s) - dmt1 , transferrin , serum iron , lymphocyte , endocrinology , medicine , ferritin , transferrin receptor , metabolism , ferroportin , iron deficiency , hepcidin , hemoglobin , anemia , physiology , immunology , biology , transporter , biochemistry , gene

Studies using cerebrospinal fluid, magnetic resonance imaging, and autopsy tissue have implicated a primary role for brain iron insufficiency in restless legs syndrome (RLS). If the abnormalities of brain iron regulation reflect a basic disturbance of iron metabolism, then this might be expressed at least partially in some peripheral systems. Thus the study aim was to determine whether patients with RLS and control subjects show differences in lymphocyte iron regulator proteins.

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