Systemic vs. Central Administration of Common Hypnotics Reveals Opposing Effects on Genioglossus Muscle Activity in Rats | Zendy

Eileen Park | Zendy; Magdy Younes | Zendy; Hattie Liu | Zendy; Xia Liu | Zendy; Richard L. Horner | Zendy

Open Access

Systemic vs. Central Administration of Common Hypnotics Reveals Opposing Effects on Genioglossus Muscle Activity in Rats

Author(s) -

Eileen Park,

Magdy Younes,

Hattie Liu,

Xia Liu,

Richard L. Horner

Publication year - 2008

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/31.3.355

Subject(s) - sedative , genioglossus , arousal , medicine , anesthesia , systemic administration , stimulation , gabaa receptor , pharmacology , neuroscience , receptor , psychology , biology , obstructive sleep apnea , microbiology and biotechnology , in vivo

To determine if systemic administration of selected sedative-hypnotics that modulate the function of the y-amino-butyric acid-A (GABAA) receptor can: (i) delay arousal thereby allowing genioglossus (GG) activity to increase more in response to respiratory stimulation during sleep, (ii) also cause the robust increase in GG activity during undisturbed sleep recently observed with barbiturates. We also determined effects on GG activity with local application to the hypoglossal motor nucleus (HMN).

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