Sleep-Stabilizing Effects of E-6199, Compared to Zopiclone, Zolpidem and THIP in Mice | Zendy

C Alexandre | Zendy; Alberto Dordal | Zendy; Ramon Aixendri | Zendy; Antonio Guzmán | Zendy; M. Hamon | Zendy; Joëlle Adrien | Zendy

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Sleep-Stabilizing Effects of E-6199, Compared to Zopiclone, Zolpidem and THIP in Mice

Author(s) -

C Alexandre,

Alberto Dordal,

Ramon Aixendri,

Antonio Guzmán,

M. Hamon,

Joëlle Adrien

Publication year - 2008

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/31.2.259

Subject(s) - zolpidem , non rapid eye movement sleep , zopiclone , hypnotic , anesthesia , psychology , slow wave sleep , wakefulness , triazolam , sleep (system call) , insomnia , medicine , electroencephalography , benzodiazepine , neuroscience , psychiatry , receptor , operating system , computer science

Gamma aminobutyric acid (GABA)A receptor modulators constitute the majority of clinically used sedative-hypnotics. These compounds have the capacity to initiate and maintain sleep, but decrease REM sleep and delta activity within NREM sleep. In order to avoid such sleep adverse effects, the development of novel compounds remains of interest.

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