Rapid Eye Movement Sleep Deprivation Contributes to Reduction of Neurogenesis in the Hippocampal Dentate Gyrus of the Adult Rat | Zendy

Rubén Guzmán-Marı́n | Zendy; Natalia Suntsova | Zendy; Tariq Bashir | Zendy; Robert Nienhuis | Zendy; Ronald Szymusiak | Zendy; Dennis McGinty | Zendy

Open Access

Rapid Eye Movement Sleep Deprivation Contributes to Reduction of Neurogenesis in the Hippocampal Dentate Gyrus of the Adult Rat

Author(s) -

Rubén Guzmán-Marı́n,

Natalia Suntsova,

Tariq Bashir,

Robert Nienhuis,

Ronald Szymusiak,

Dennis McGinty

Publication year - 2008

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/31.2.167

Subject(s) - neurogenesis , dentate gyrus , hippocampal formation , sleep (system call) , non rapid eye movement sleep , sleep deprivation , rapid eye movement sleep , neuroscience , proliferation marker , hippocampus , endocrinology , medicine , eye movement , biology , circadian rhythm , immunohistochemistry , computer science , operating system

The dentate gyrus (DG) of the adult hippocampus contains progenitor cells, which have potential to differentiate into neurons. Previously we reported that 96 hours of total sleep deprivation reduces neurogenesis in the DG of adult rats. Loss of either non-rapid eye movement (NREM) or rapid eye movement (REM) sleep could have contributed to the effect of total sleep deprivation. The present study assessed the effect of 4 days of REM sleep deprivation (REMD) on neurogenesis.

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