Open AccessIdentification of Differentially Expressed Genes in Blood Cells of Narcolepsy Patients
Author(s) -
Susumu Tanaka,
Yutaka Honda,
Makoto Honda
Publication year - 2007
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.1093/sleep/30.8.974
Subject(s) - narcolepsy , human leukocyte antigen , immune system , immunology , cataplexy , gene , medicine , antigen , biology , genetics , psychiatry , modafinil
A close association between the human leukocyte antigen (HLA)-DRB1*1501/DQB1*0602 and abnormalities in some inflammatory cytokines have been demonstrated in narcolepsy. Specific alterations in the immune system have been suggested to occur in this disorder. We attempted to identify alterations in gene expression underlying the abnormalities in the blood cells of narcoleptic patients.
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