Pentobarbital Sedation Increases Genioglossus Respiratory Activity in Sleeping Rats | Zendy

Magdy Younes | Zendy; Eileen Park | Zendy; Richard L. Horner | Zendy

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Pentobarbital Sedation Increases Genioglossus Respiratory Activity in Sleeping Rats

Author(s) -

Magdy Younes,

Eileen Park,

Richard L. Horner

Publication year - 2007

Publication title -

sleep

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/30.4.478

Subject(s) - genioglossus , pentobarbital , anesthesia , arousal , sedation , placebo , medicine , psychology , endocrinology , obstructive sleep apnea , neuroscience , alternative medicine , pathology

To determine whether certain sedatives may, by increasing arousal threshold, allow pharyngeal dilator muscle activity to increase more in response to chemical stimuli before arousal occurs. DESIGN, PARTICIPANTS AND INTERVENTIONS: Thirteen chronically instrumented rats were studied during sleep following injections of placebo or sedating doses of pentobarbital (10 mg/kg). Intermittently, inspired CO2 was increased gradually until arousal occurred.

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