Evaluation of Hypothalamic-Specific Autoimmunity in Patients With Narcolepsy | Zendy

José Rodríguez | Zendy; Lídia Sabater | Zendy; Francesc Graus | Zendy; Álex Iranzo | Zendy; Joan Santamaría | Zendy

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Evaluation of Hypothalamic-Specific Autoimmunity in Patients With Narcolepsy

Author(s) -

José Rodríguez,

Lídia Sabater,

Francesc Graus,

Álex Iranzo,

Joan Santamaría

Publication year - 2007

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/30.1.27

Subject(s) - narcolepsy , autoimmunity , cataplexy , etiology , medicine , immunology , antibody , hypothalamus , endocrinology , neurology , psychiatry

An autoimmune-mediated mechanism is considered the most probable etiology for narcolepsy. However, this hypothesis remains unproven. Since narcolepsy is characterized by dysfunction of the hypothalamic hypocretinergic (orexinergic) system, we evaluated the presence of hypothalamic-specific antibodies in sera and CSF of 25 hypocretin-deficient and 6 non-deficient narcoleptic patients by immunohistochemistry and analyzing a screening of a rat cDNA expression hypothalamic library. There was no hypothalamic-specific reactivity in serum or CSF by inmmunohistochemistry. The screening of the hypothalmic library detected some reactive clones but not a common reactivity. Our study did not find any evidence of hypothalamic-specific autoimmunity in narcolepsy.

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