Detection of Autoantibodies Against Hypocretin, hcrtr1, and hcrtr2 in Narcolepsy: Anti-Hcrt System Antibody in Narcolepsy | Zendy

Susumu Tanaka | Zendy; Yutaka Honda | Zendy; Yuichi Inoue | Zendy; Makoto Honda | Zendy

Open Access

Detection of Autoantibodies Against Hypocretin, hcrtr1, and hcrtr2 in Narcolepsy: Anti-Hcrt System Antibody in Narcolepsy

Author(s) -

Susumu Tanaka,

Yutaka Honda,

Yuichi Inoue,

Makoto Honda

Publication year - 2006

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/29.5.633

Subject(s) - narcolepsy , cataplexy , autoantibody , excessive daytime sleepiness , medicine , pathophysiology , autoimmunity , immunology , endocrinology , sleep disorder , psychology , antibody , psychiatry , neurology , cognition

The impairment of hypocretin neurotransmission system is considered to play a major role in the pathophysiology of narcolepsy. It has been hypothesized that autoimmune abnormalities underlie the etiology of narcolepsy, based on the tight association with HLA-DRB1*1501/ DQB1*0602. It remains unclear if autoantibodies against hypocretin receptors (hcrtrl and hcrtr2) are involved in narcolepsy.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research