Sex Differences in Susceptibility to Oxidative Injury and Sleepiness From Intermittent Hypoxia | Zendy

Benjamin Sanfilippo-Cohn | Zendy; Saien Lai | Zendy; Guanxia Zhan | Zendy; Polina Fenik | Zendy; Domenico Praticò | Zendy; Emílio Mazza | Zendy; Sigrid C. Veasey | Zendy

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Sex Differences in Susceptibility to Oxidative Injury and Sleepiness From Intermittent Hypoxia

Author(s) -

Benjamin Sanfilippo-Cohn,

Saien Lai,

Guanxia Zhan,

Polina Fenik,

Domenico Praticò,

Emílio Mazza,

Sigrid C. Veasey

Publication year - 2006

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/29.2.152

Subject(s) - nicotinamide adenine dinucleotide phosphate , hypoxia (environmental) , intermittent hypoxia , oxidative stress , oxidative phosphorylation , obstructive sleep apnea , apnea , medicine , sleep apnea , endocrinology , anesthesia , biology , oxidase test , chemistry , oxygen , biochemistry , organic chemistry , enzyme

Adult male mice exposed to long-term intermittent hypoxia (LTIH), modeling sleep apnea oxygenation patterns, develop nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent residual hypersomnolence and oxidative injury in select brain regions, including wake-active regions. Premenopausal females are less susceptible to selective oxidative brain injuries. We sought to determine whether female mice exposed to LTIH would confer resistance to LTIH-induced wake impairments and oxidative injuries.

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