The Kleine-Levin Syndrome: A Paramedian Thalamic Dysfunction?

The present report of brain imaging SPECT in 5 subjects affected with the Kleine-Levin syndrome, documenting a more than 30% diminished perfusion of both thalami during a symptomatic period in comparison with an asymptomatic period in all cases, plus an hypoperfusion in the basal ganglia and various cortical sites in a majority of cases, can be considered as a breakthrough in the rather uneventful history of the syndrome. Based on previous experience the authors have attempted a comparison between their current findings in Kleine-Levin syndrome patients and previous findings in a 23 and a 28 years old black men diagnosed with paramedian thalamic lesions. 12 These