The Suprachiasmatic Nucleus Regulates Sleep Timing and Amount in Mice | Zendy

Amy Easton | Zendy; Peter Meerlo | Zendy; Bernard M. Bergmann | Zendy; Fred W. Turek | Zendy

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The Suprachiasmatic Nucleus Regulates Sleep Timing and Amount in Mice

Author(s) -

Amy Easton,

Peter Meerlo,

Bernard M. Bergmann,

Fred W. Turek

Publication year - 2004

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/27.7.1307

Subject(s) - free running sleep , neuroscience of sleep , circadian rhythm , sleep deprivation , wakefulness , non rapid eye movement sleep , suprachiasmatic nucleus , endocrinology , sleep (system call) , medicine , sleep debt , rapid eye movement sleep , sleep onset , vigilance (psychology) , psychology , light effects on circadian rhythm , neuroscience , biology , eye movement , electroencephalography , insomnia , psychiatry , computer science , operating system

Sleep is regulated by circadian and homeostatic processes. The circadian pacemaker, located in the suprachiasmatic nuclei (SCN), regulates the timing and consolidation of the sleep-wake cycle, while a homeostatic mechanism governs the accumulation of sleep debt and sleep recovery. Recent studies using mice with deletions or mutations of circadian genes show that components of the circadian pacemaker can influence the total amount of baseline sleep and recovery from sleep deprivation, indicating a broader role for the SCN in sleep regulation.

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