Twenty-Four—Hour Disruption of the Sleep-Wake Cycle and Sleep-Onset REM-Like Episodes in a Rat Model of African Trypanosomiasis | Zendy

Annabelle Darsaud | Zendy; Lionel Bourdon | Zendy; Sarah K. Mercier | Zendy; Florian Chapotot | Zendy; Bernard Bouteille | Zendy; Raymond Cespuglio | Zendy; Alain Buguet | Zendy

Open Access

Twenty-Four—Hour Disruption of the Sleep-Wake Cycle and Sleep-Onset REM-Like Episodes in a Rat Model of African Trypanosomiasis

Author(s) -

Annabelle Darsaud,

Lionel Bourdon,

Sarah K. Mercier,

Florian Chapotot,

Bernard Bouteille,

Raymond Cespuglio,

Alain Buguet

Publication year - 2004

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/27.1.42

Subject(s) - african trypanosomiasis , trypanosoma brucei , wakefulness , sleep (system call) , trypanosomiasis , slow wave sleep , polysomnography , rapid eye movement sleep , circadian rhythm , biology , medicine , endocrinology , eye movement , immunology , neuroscience , electroencephalography , biochemistry , gene , computer science , operating system

Patients with human African trypanosomiasis (sleeping sickness) due to the inoculation of Trypanosoma brucei gambiense or rhodesiense show a major disruption of the 24-hour sleep-wake distribution, accompanied by the occurrence of sleep-onset rapid-eye-movement (REM) sleep episodes, proportional to the severity of the illness. Although animal models of human African trypanosomiasis have been developed to understand the pathogenic mechanisms leading to immune alterations, the development of an animal model featuring the alterations of endogenous biologic rhythms remains a necessity.

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