Sleep Deprivation and Cellular Responses to Oxidative Stress
Author(s) -
Anupama Gopalakrishnan,
Li Li Ji,
Chiara Cirelli
Publication year - 2004
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.1093/sleep/27.1.27
Subject(s) - sleep deprivation , oxidative stress , lipid peroxidation , endocrinology , medicine , sleep (system call) , superoxide dismutase , oxidative phosphorylation , privation , antioxidant , chemistry , circadian rhythm , biochemistry , computer science , operating system
It has been hypothesized that sleep deprivation represents an oxidative challenge for the brain and that sleep may have a protective role against oxidative damage. This study was designed to test this hypothesis by measuring in rats the effects of sleep loss on markers of oxidative stress (oxidant production and antioxidant enzyme activities) as well as on markers of cellular oxidative damage (lipid peroxidation and protein oxidation).
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