Decreased Hypocretin-1 (Orexin-A) Levels in the Cerebrospinal Fluid of Patients with Myotonic Dystrophy and Excessive Daytime Sleepiness | Zendy

José Rodríguez | Zendy; Ling Lin | Zendy; Álex Iranzo | Zendy; David Genı́s | Zendy; Marı́a José Martı́ | Zendy; Joan Santamaría | Zendy; Emmanuel Mignot | Zendy

Open Access

Decreased Hypocretin-1 (Orexin-A) Levels in the Cerebrospinal Fluid of Patients with Myotonic Dystrophy and Excessive Daytime Sleepiness

Author(s) -

José Rodríguez,

Ling Lin,

Álex Iranzo,

David Genı́s,

Marı́a José Martı́,

Joan Santamaría,

Emmanuel Mignot

Publication year - 2003

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/26.3.287

Subject(s) - narcolepsy , myotonic dystrophy , excessive daytime sleepiness , multiple sleep latency test , medicine , cataplexy , sleep disorder , myotonia , endocrinology , orexin , psychology , neurology , psychiatry , insomnia , neuropeptide , receptor

Myotonic dystrophy type 1 is a multisystem disorder with myotonia, muscle weakness, cataracts, endocrine dysfunction, and intellectual impairment. This disorder is caused by a CTG triplet expansion in the 3' untranslated region of the DMPK gene on 19q13. Myotonic dystrophy type 1 is frequently associated with excessive daytime sleepiness, sharing with narcolepsy a short sleep latency and the presence of sleep-onset rapid eye movement periods during the Multiple Sleep Latency Test. Since narcolepsy is characterized by a dysfunction of the hypothalamic hypocretin system, we investigated whether patients with myotonic dystrophy type 1 with excessive daytime sleepiness have abnormalities in the hypocretin system.

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