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Hypocretin (orexin) deficiency (&lt; 40 pg/ml) is highly associated with narcolepsy with cataplexy (89.5%) and more specifically with patients with cataplexy who are HLA DQB1*0602 positive (95.7%). The relationship between hypocretin-1 levels and narcolepsy without cataplexy or the DQB1*0602 allele is less clear.

Hypocretin (Orexin) Levels in Cerebrospinal Fluid of Patients with Narcolepsy: Relationship to Cataplexy and HLA DQB1*0602 Status