Open AccessHypocretin (Orexin) Levels in Cerebrospinal Fluid of Patients with Narcolepsy: Relationship to Cataplexy and HLA DQB1*0602 Status
Author(s) -
Lois E. Krahn,
V. Shane Pankratz,
Lawrence K. Oliver,
Bradley F. Boeve,
Michael H. Silber
Publication year - 2002
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.1093/sleep/25.7.733
Subject(s) - cataplexy , narcolepsy , orexin , hla dqb1 , human leukocyte antigen , medicine , psychology , sleep paralysis , sleep disorder , endocrinology , gastroenterology , psychiatry , neurology , immunology , insomnia , neuropeptide , antigen , receptor
Hypocretin (orexin) deficiency (< 40 pg/ml) is highly associated with narcolepsy with cataplexy (89.5%) and more specifically with patients with cataplexy who are HLA DQB1*0602 positive (95.7%). The relationship between hypocretin-1 levels and narcolepsy without cataplexy or the DQB1*0602 allele is less clear.
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