Open AccessMotor Overactivity and Loss of Motor Circadian Rhythm in Fatal Familial Insomnia: An Actigraphic Study
Author(s) -
Giuseppe Plazzi,
Yves Schütz,
Pietro Cortelli,
Federica Provini,
Patrizia Avoni,
Erika Heikkilä,
Paolo Tinuper,
Laura Solieri,
E Lugaresi,
Pasquale Montagna
Publication year - 1997
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.1093/sleep/20.9.739
Subject(s) - actigraphy , circadian rhythm , medicine , bed rest , rhythm , motor activity , insomnia , sleep diary , rest (music) , dark therapy , sleep (system call) , anesthesia , physical medicine and rehabilitation , audiology , psychology , psychiatry , computer science , operating system
The 24-hour rest-activity pattern and the amount of motor activity was studied in a patient with fatal familial insomnia (FFI) by means of wrist actigraphy. During the study, the patient underwent indirect calorimetry. The 52-day recording showed severe disruption of the 24-hour rest-activity pattern with increased motor activity up to 80%. The 24-hour energy expenditure, assayed in a respiration chamber, was strikingly elevated by 60%. Chronic motor overactivity and loss of circadian rest-activity rhythm may play a role in the progressive metabolic exhaustion leading to death in FFI patients.
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