The Effect of Gamma-Hydroxybutyrate on Nocturnal and Diurnal Sleep of Normal Subjects: Further Considerations on REM Sleep-Triggering Mechanisms | Zendy

O Lapierre | Zendy; J. Montpiaisir | Zendy; M. Lamarre | Zendy; MarcAndré Bedard | Zendy

Open Access

The Effect of Gamma-Hydroxybutyrate on Nocturnal and Diurnal Sleep of Normal Subjects: Further Considerations on REM Sleep-Triggering Mechanisms

Author(s) -

O Lapierre,

J. Montpiaisir,

M. Lamarre,

MarcAndré Bedard

Publication year - 1990

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/13.1.24

Subject(s) - nap , bedtime , non rapid eye movement sleep , morning , sleep (system call) , narcolepsy , sleep stages , slow wave sleep , psychology , sleep onset , nocturnal , circadian rhythm , rapid eye movement sleep , medicine , anesthesia , polysomnography , eye movement , modafinil , insomnia , psychiatry , electroencephalography , neuroscience , computer science , operating system

Gamma-hydroxybutyrate (GHB) is a drug currently used to treat narcolepsy. The present study documents its effect on sleep organization in healthy subjects. GHB and a placebo were given at bedtime and before a morning nap in a double-blind fashion. GHB administered before nocturnal or diurnal sleep increases stages 3 and 4 and decreases stage 1 non-rapid eye movement (NREM) sleep. In addition, GHB improves REM efficiency at night and reduces wake time after sleep onset when administered before a morning nap recording. GHB also slightly decreases REM latency when administered in the morning, and this effect is correlated with age. Hypotheses regarding mechanisms of action GHB and the involvement of hypothalamic structures in the regulation of REM sleep are discussed.

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