Respiratory and Hemodynamic Study During Wakefulness and Sleep in Myotonic Dystrophy | Zendy

Christian Guilleminault | Zendy; Joseph Cummiskey | Zendy; Jorge Motta | Zendy; Patricia Lynne-Davies | Zendy

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Respiratory and Hemodynamic Study During Wakefulness and Sleep in Myotonic Dystrophy

Author(s) -

Christian Guilleminault,

Joseph Cummiskey,

Jorge Motta,

Patricia Lynne-Davies

Publication year - 1978

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/1.1.19

Subject(s) - medicine , wakefulness , anesthesia , sleep apnea , hypoxemia , myotonic dystrophy , hypercapnia , apnea , sleep (system call) , ventilation (architecture) , cardiology , respiratory system , electroencephalography , mechanical engineering , psychiatry , computer science , engineering , operating system

Six young male patients with grade I (mild) myotonic dystrophy and a complaint of excessive daytime sleepiness were studied during wakefulness and sleep. Pulmonary function tests during wakefulness showed evidence of mild abnormality related to respiratory muscle weakness. During sleep, some patients developed a sleep apnea syndrome with high sleep Apnea Indices. There was no relation between hypoxic and hypercapnic ventilatory responses during wakefulness and sleep Apnea Indices. But hypoxemia and hypercapnia worsened considerably during REM sleep. Myotonic dystrophy patients with sleep apnea presented increased pulmonary and systemic arterial pressures during sleep. It was also during sleep that arrhythmias were observed.

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