Toxoplasma Gondii and Cognitive Deficits in Schizophrenia: An Animal Model Perspective | Zendy

Geetha Kannan | Zendy; Mikhail V. Pletnikov | Zendy

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Toxoplasma Gondii and Cognitive Deficits in Schizophrenia: An Animal Model Perspective

Author(s) -

Geetha Kannan,

Mikhail V. Pletnikov

Publication year - 2012

Publication title -

schizophrenia bulletin

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.823

H-Index - 190

eISSN - 1745-1707

pISSN - 0586-7614

DOI - 10.1093/schbul/sbs079

Subject(s) - toxoplasma gondii , cognition , schizophrenia (object oriented programming) , psychology , animal cognition , affect (linguistics) , neuroscience , psychiatry , medicine , immunology , communication , antibody

Cognitive deficits are a core feature of schizophrenia. Epidemiological evidence indicates that microbial pathogens may contribute to cognitive impairment in patients with schizophrenia. Exposure to Toxoplasma gondii (T. gondii) has been associated with cognitive deficits in humans. However, the mechanisms whereby the parasite impacts cognition remain poorly understood. Animal models of T. gondii infection may aid in elucidating the underpinnings of cognitive dysfunction. Here, we (1) overview the literature on the association of T. gondii infection and cognitive impairment, (2) critically analyze current rodent models of cognitive deficits resulting from T. gondii infection, and (3) explore possible mechanisms whereby the parasite may affect cognitive function.

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