Open AccessRare CNVs and Tag SNPs at 15q11.2 Are Associated With Schizophrenia in the Han Chinese Population
Author(s) -
Qian Zhao,
Tao Li,
Xinzhi Zhao,
Ke Huang,
Ti Wang,
Zhiqiang Li,
Jue Ji,
Zhen Zeng,
Zhao Zhang,
Kan Li,
Guoyin Feng,
David St Clair,
Lin He,
Yongyong Shi
Publication year - 2012
Publication title -
schizophrenia bulletin
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.823
H-Index - 190
eISSN - 1745-1701
pISSN - 0586-7614
DOI - 10.1093/schbul/sbr197
Subject(s) - single nucleotide polymorphism , copy number variation , locus (genetics) , genetics , schizophrenia (object oriented programming) , population , biology , medicine , gene , psychiatry , genotype , genome , environmental health
Rare copy number variations (CNVs) were involved in the etiology of neuropsychiatric disorders, and some of them appeared to be shared risk factors for several different diseases. One of those promising loci is the CNV at 15q11.2, including 4 genes, TUBGCP5, CYFIP1, NIPA2, and NIPA1. Several studies showed that microdeletions at this locus were significant associated with schizophrenia. In the current study, we investigated the role of both rare CNVs and common single nucleotide polymorphisms (SNPs) at 15q11.2 in schizophrenia in the Chinese Han population.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom