Dopamine D2 Receptor Occupancy and Cognition in Schizophrenia: Analysis of the CATIE Data | Zendy

Hitoshi Sakurai | Zendy; Robert R. Bies | Zendy; T. Scott Stroup | Zendy; Richard S.E. Keefe | Zendy; Tarek K. Rajji | Zendy; Takefumi Suzuki | Zendy; David C. Mamo | Zendy; Bruce G. Pollock | Zendy; Koichiro Watanabe | Zendy; Masaru Mimura | Zendy; Hiroyuki Uchida | Zendy

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Dopamine D2 Receptor Occupancy and Cognition in Schizophrenia: Analysis of the CATIE Data

Author(s) -

Hitoshi Sakurai,

Robert R. Bies,

T. Scott Stroup,

Richard S.E. Keefe,

Tarek K. Rajji,

Takefumi Suzuki,

David C. Mamo,

Bruce G. Pollock,

Koichiro Watanabe,

Masaru Mimura,

Hiroyuki Uchida

Publication year - 2012

Publication title -

schizophrenia bulletin

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.823

H-Index - 190

eISSN - 1745-1707

pISSN - 0586-7614

DOI - 10.1093/schbul/sbr189

Subject(s) - antipsychotic , neurocognitive , dopamine receptor d2 , psychology , olanzapine , vigilance (psychology) , psychosis , ziprasidone , schizophrenia (object oriented programming) , risperidone , population , clinical psychology , psychiatry , medicine , cognition , dopamine , neuroscience , environmental health

Antipsychotic drugs exert antipsychotic effects by blocking dopamine D2 receptors in the treatment of schizophrenia. However, effects of D2 receptor blockade on neurocognitive function still remain to be elucidated. The objective of this analysis was to evaluate impacts of estimated dopamine D2 receptor occupancy with antipsychotic drugs on several domains of neurocognitive function in patients with schizophrenia in the Clinical Antipsychotic Trials in Intervention Effectiveness (CATIE) trial.

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