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Second-Generation Antipsychotic Drugs and Extrapyramidal Side Effects: A Systematic Review and Meta-analysis of Head-to-Head Comparisons
Author(s) -
Christine RummelKluge,
Katja Komossa,
Sandra Schwarz,
Heike Hunger,
Franziska Schmid,
Werner Kissling,
John M. Davis,
Stefan Leucht
Publication year - 2010
Publication title -
schizophrenia bulletin
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.823
H-Index - 190
eISSN - 1745-1707
pISSN - 0586-7614
DOI - 10.1093/schbul/sbq042
Subject(s) - ziprasidone , quetiapine , amisulpride , olanzapine , sertindole , clozapine , risperidone , extrapyramidal symptoms , antipsychotic , positive and negative syndrome scale , medicine , aripiprazole , psychology , akathisia , atypical antipsychotic , psychiatry , pharmacology , schizophrenia (object oriented programming) , psychosis
While all second-generation antipsychotics (SGAs) are promoted for having a low risk of extrapyramidal side effects (EPS), clinical observations suggest differences between the various agents. Nevertheless, this question has never been examined in a systematic review and meta-analysis of head-to-head comparisons.

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