Searching for Unique Endophenotypes for Schizophrenia and Bipolar Disorder Within Neural Circuits and Their Molecular Regulatory Mechanisms | Zendy

Francine M. Beneš | Zendy

Open Access

Searching for Unique Endophenotypes for Schizophrenia and Bipolar Disorder Within Neural Circuits and Their Molecular Regulatory Mechanisms

Author(s) -

Francine M. Beneš

Publication year - 2007

Publication title -

schizophrenia bulletin

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.823

H-Index - 190

eISSN - 1745-1707

pISSN - 0586-7614

DOI - 10.1093/schbul/sbm064

Subject(s) - endophenotype , schizophrenia (object oriented programming) , bipolar disorder , neuroscience , psychology , biological neural network , schizophrenia research , psychiatry , cognition

The endophenotype is a construct that has utility for the study of postmortem brains from patients with psychotic disorders. By identifying networks of genes that show changes in expression within specific neuronal populations implicated in the pathophysiology of schizophrenia and bipolar disorder, it may be possible to move toward understanding these disorders at the cellular and molecular levels. The ultimate goal is to characterize their respective underlying genotypes.

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