Open AccessSchizophrenia Polygenic Risk and Experiences of Childhood Adversity: A Systematic Review and Meta-analysis
Author(s) -
Grace Woolway,
Sophie E. Smart,
Amy Lynham,
Jenny Lloyd,
Michael J. Owen,
Ian Jones,
James Walters,
Sophie E. Legge
Publication year - 2022
Publication title -
schizophrenia bulletin
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.823
H-Index - 190
eISSN - 1745-1701
pISSN - 0586-7614
DOI - 10.1093/schbul/sbac049
Subject(s) - meta analysis , polygenic risk score , schizophrenia (object oriented programming) , psychology , psychiatry , clinical psychology , medicine , genetics , biology , single nucleotide polymorphism , gene , genotype
Schizophrenia has been robustly associated with multiple genetic and environmental risk factors. Childhood adversity is one of the most widely replicated environmental risk factors for schizophrenia, but it is unclear if schizophrenia genetic risk alleles contribute to this association.
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