Open AccessMonoamine Oxidase Substrates and Substrate Affinity
Author(s) -
Edward F. Domino
Publication year - 1980
Publication title -
schizophrenia bulletin
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.823
H-Index - 190
eISSN - 1745-1707
pISSN - 0586-7614
DOI - 10.1093/schbul/6.2.292
Subject(s) - clorgyline , monoamine oxidase , substrate (aquarium) , monoamine oxidase b , chemistry , substrate specificity , monoamine neurotransmitter , endogeny , enzyme , monoamine oxidase a , affinities , biochemistry , phenelzine , stereochemistry , biology , serotonin , receptor , ecology
The evidence that there are two forms of monoamine oxidase (MAO) enzymes is reviewed. On the basis of various substrate affinities, differential inhibition by deprenyl and clorgyline, and heat inactivation, there appear to be a type A and a type B MAO in various tissues. The enzymatic oxidation of telemethylhistamine (tMH) is an example of an endogenous substrate for type B MAO.
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