Dopamine Supersensitivity, Endorphin Excess, and Prostaglandin E1 Deficiency: Three Aspects of the Same Schizophrenic Elephant | Zendy

David F. Horrobin | Zendy

Open Access

Dopamine Supersensitivity, Endorphin Excess, and Prostaglandin E1 Deficiency: Three Aspects of the Same Schizophrenic Elephant

Author(s) -

David F. Horrobin

Publication year - 1978

Publication title -

schizophrenia bulletin

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.823

H-Index - 190

eISSN - 1745-1707

pISSN - 0586-7614

DOI - 10.1093/schbul/4.4.487

Subject(s) - dopamine , schizophrenia (object oriented programming) , prostaglandin e1 , prolactin , antipsychotic , psychology , endorphins , medicine , neuroscience , endocrinology , psychiatry , hormone

The author presents a hypothesis relating prostaglandin E1 (PGE1) deficiency to schizophrenia. The hypothesis is consistent with the importance of prolactin-stimulating properties in currently used antipsychotic drugs, the effect of prolactin on PGE1 synthesis, and the deficiency of PGE1 regulation in schizophrenic platelets. The author relates the PGE1 deficiency hypothesis to theories implicating dopamine and endorphins in the etiology of schizophrenia. A clinical trial in chronic schizophrenics has suggested the possible therapeutic efficacy of penicillin, a drug without dopamine-blocking actions which can stimulate PGE1 synthesis directly.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research