Quantitative D2 Dopamine Receptor PET and Structural MRI Changes in Late-Onset Schizophrenia | Zendy

Godfrey D. Pearlson | Zendy; Larry E. Tune | Zendy; Dean F. Wong | Zendy; Elizabeth Aylward | Zendy; Patrick E. Barta | Zendy; Richard E. Powers | Zendy; Allen Y. Tien | Zendy; G A Chase | Zendy; Gordon J. Harris | Zendy; Peter V. Rabins | Zendy

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Quantitative D2 Dopamine Receptor PET and Structural MRI Changes in Late-Onset Schizophrenia

Author(s) -

Godfrey D. Pearlson,

Larry E. Tune,

Dean F. Wong,

Elizabeth Aylward,

Patrick E. Barta,

Richard E. Powers,

Allen Y. Tien,

G A Chase,

Gordon J. Harris,

Peter V. Rabins

Publication year - 1993

Publication title -

schizophrenia bulletin

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.823

H-Index - 190

eISSN - 1745-1707

pISSN - 0586-7614

DOI - 10.1093/schbul/19.4.783

Subject(s) - schizophrenia (object oriented programming) , magnetic resonance imaging , positron emission tomography , etiology , neuroimaging , dopamine receptor d2 , dopamine receptor , medicine , psychology , psychosis , dopamine , disease , psychiatry , neuroscience , radiology

Late-onset schizophrenia (LOS) is likely a syndrome of diverse etiology. In a series of related studies, we compared LOS patients with normal controls, elderly patients with early-onset schizophrenia (EOS), and Alzheimer's disease patients, using magnetic resonance imaging (MRI) and neuroreceptor positron emission tomography measures, which had previously been reported to be abnormal in EOS. EOS and LOS patients showed similar MRI changes. LOS drug-naive patients had elevated Bmax (receptor density) values for dopamine D2 receptors compared with age and gender norms, a phenomenon previously reported by our group in young schizophrenia patients.

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