Open AccessExpression of cannabinoid receptor 2 and its inhibitory effects on synovial fibroblasts in rheumatoid arthritis
Author(s) -
Huan Gui,
Xia Liu,
Zhiwei Wang,
Dongyi He,
DingFeng Su,
ShengMing Dai
Publication year - 2014
Publication title -
rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.957
H-Index - 173
eISSN - 1462-0332
pISSN - 1462-0324
DOI - 10.1093/rheumatology/ket447
Subject(s) - proinflammatory cytokine , medicine , blot , receptor , cannabinoid receptor type 2 , matrix metalloproteinase , p38 mitogen activated protein kinases , endocrinology , kinase , inflammation , agonist , mapk/erk pathway , cannabinoid receptor , biology , microbiology and biotechnology , biochemistry , gene
Recent studies have suggested immunomodulatory and anti-inflammatory effects of cannabinoid receptor 2 (CB2R) activation, which shows no psychoactivity. However, it is still unclear whether CB2R is expressed in fibroblast-like synoviocytes (FLS) of RA. In this study we investigated whether CB2R is expressed in FLS of RA, and whether CB2R activation modulates the function of RA-FLS.