Open AccessIL-7R low memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus
Author(s) -
Jung-Sik Kim,
Bon A. Cho,
Ji Hyun Sim,
Kamini Shah,
Connie M. Woo,
Eun Bong Lee,
Dong Sup Lee,
Jae Seung Kang,
Wang Jae Lee,
ChungGyu Park,
Joe Craft,
Insoo Kang,
Hang Rae Kim
Publication year - 2012
Publication title -
rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.957
H-Index - 173
eISSN - 1462-0332
pISSN - 1462-0324
DOI - 10.1093/rheumatology/kes100
Subject(s) - cytotoxic t cell , cd8 , immunology , interleukin 21 , flow cytometry , medicine , antigen , biology , in vitro , biochemistry
Human effector memory (EM) CD8(+) T cells include IL-7Rα(high) and IL-7Rα(low) cells with distinct cellular characteristics, including the expression of cytotoxic molecules. Both NK cells and the NK cell-associated molecule 2B4 that is expressed on CD8(+) T cells promote cytotoxicity. Here we analysed the expression of 2B4 on IL-7Rα(high) and IL-7Rα(low) EM CD8(+) T cells and its contribution to cytotoxicity. We also analysed the frequency of IL-7Rα(high) and IL-7Rα(low) EM CD8(+) T cells in patients with SLE or lupus and in healthy individuals given the potential role of cytotoxic CD8(+) T cells in the pathogenesis of lupus.