Open AccessProphylactic but not therapeutic activity of a monoclonal antibody that neutralizes the binding of VEGF-B to VEGFR-1 in a murine collagen-induced arthritis model
Author(s) -
Arne W. Mould,
Pierre Scotney,
Sonia Greco,
Nicholas K. Hayward,
Andrew D. Nash,
Graham F. Kay
Publication year - 2007
Publication title -
rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.957
H-Index - 173
eISSN - 1462-0332
pISSN - 1462-0324
DOI - 10.1093/rheumatology/kem369
Subject(s) - medicine , monoclonal antibody , arthritis , pathogenesis , booster dose , antibody , immunology , intradermal injection , isotype , intraperitoneal injection , adjuvant , neutralizing antibody , pharmacology , immunization
To assess the therapeutic potential of a mAb that neutralizes the binding of VEGF-B to VEGFR-1, to inhibit the pathogenesis of CIA in mice.