Open AccessAnti-malarial agent artesunate inhibits TNF- -induced production of proinflammatory cytokines via inhibition of NF- B and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes
Author(s) -
Hanshi Xu,
Yongqing He,
Xia Yang,
Liuqin Liang,
Zhi-Hui Zhan,
Y. Ye,
Li Fan,
Lin Sun
Publication year - 2007
Publication title -
rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.957
H-Index - 173
eISSN - 1462-0332
pISSN - 1462-0324
DOI - 10.1093/rheumatology/kem014
Subject(s) - artesunate , protein kinase b , p38 mitogen activated protein kinases , proinflammatory cytokine , pyrrolidine dithiocarbamate , tumor necrosis factor alpha , kinase , signal transduction , medicine , iκbα , pharmacology , microbiology and biotechnology , nf κb , biology , protein kinase a , immunology , inflammation , plasmodium falciparum , malaria
Recent studies indicate that the anti-malarial agent artemisinin and its derivatives may exert an anti-inflammatory effect. In this study, we explored the effect of artesunate, an artemisinin derivative, on tumour necrosis factor (TNF)-alpha-induced production of interleukins, IL-1beta, IL-6 and IL-8, in human rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS), and further investigated the signal mechanism by which this compound modulates those cytokines' production.